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[Current concepts of the structure and functions of retinoid receptors]
D B Uteshev1, A V Sergeev, B S Uteshev
1Clinic of Internal Diseases, Heidelberg University, Deutschland.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|February 4, 1999
Abstract:
The article discusses the principal structure of nuclear receptors. The structure and function of retinoid receptors, their main ligands and inhibitors are analysed. Data (experimental and clinical) concerning the immunotropic antineoplastic and cardiovascular activity of the main retinoids are given.
Insights
This study explores nuclear receptor structures, focusing on retinoid receptors. It details their ligands, inhibitors, and therapeutic potential in cancer and cardiovascular diseases.
Area of Science:
- Molecular Biology
- Endocrinology
- Pharmacology
Context:
- Nuclear receptors are crucial regulators of gene expression.
- Retinoid receptors play significant roles in cellular differentiation and homeostasis.
- Understanding their structure is key to developing targeted therapies.
Purpose:
- To elucidate the principal structure of nuclear receptors.
- To analyze the structure-function relationship of retinoid receptors.
- To review ligands, inhibitors, and therapeutic activities of retinoids.
Summary:
- The article details the fundamental structure of nuclear receptors.
- It examines the structure and function of retinoid receptors, including their primary ligands and inhibitors.
- Experimental and clinical data on the immunotropic, antineoplastic, and cardiovascular effects of key retinoids are presented.
Impact:
- Provides insights into the molecular mechanisms of retinoid action.
- Highlights the therapeutic potential of retinoids in oncology and cardiology.
- Serves as a resource for researchers in nuclear receptor signaling and drug development.