Interactions between platelets and leukocytes during hemodialysis
M Bonomini1, V Sirolli, S Stuard
1Institute of Nephrology, Department of Medicine, Gabriele d'Annunzio University, Chieti, Italy. M.Bonomini@unich.it
Abstract:
The formation of platelet-leukocyte microaggregates has been observed in a variety of conditions. When platelets and leukocytes coaggregate, in general, a reciprocal activation occurs when both cells are activated, and the interactions between activated platelets and leukocytes may be relevant in both hemostasis and inflammatory processes. The study of platelet-leukocyte interactions in hemodialysis offers the novel aspect of cellular-cellular interaction as a new parameter for evaluating the biocompatibility of dialyzer membranes. This article reviews the investigations of the interactions between platelets and leukocytes during hemodialysis and the pathophysiologic implications which may stem from such interactions.
More Related Videos
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Structure and Function of Platelets
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Hemodialysis I: Introduction


