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Infective endocarditis caused by Veillonella of dental origin
G Prpić-Mehicić1, T Marsan, I Miletić
1Department of Dental Pathology, School of Dentistry, Zagreb, Croatia.
Collegium Antropologicum
|February 10, 1999
Summary
Veillonella bacteria can enter the bloodstream with S. mutans, potentially causing infective endocarditis in rats. Further research is needed to understand its role in pure cultures.
Area of Science:
- Microbiology
- Oral Health
- Infectious Diseases
Background:
- Veillonella species are oral bacteria.
- Infective endocarditis is a serious heart infection.
Purpose of the Study:
- To investigate Veillonella's role in causing bacteremia and endocarditis.
- To examine Veillonella in pure and mixed cultures with S. mutans.
- To use a rat incisor infection model.
Main Methods:
- Inoculation of rat incisors with Veillonella (pure/mixed with S. mutans).
- Hemoculture and histopathological analysis of endocardial tissue.
- Observation over 7, 21, and 52 days.
Main Results:
- Bacteremia detected in mixed infections after 21 days.
- Endocardial tissue changes observed in 12.96% of cases.
- Acute and chronic endocarditis linked to infection duration.
Conclusions:
- Veillonella can enter circulation with S. mutans via pulp tissue in rats.
- Veillonella may contribute to infective endocarditis.
- The mechanism of endocarditis in pure Veillonella cultures requires further investigation.