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[Oxatomide in the treatment of atopic dermatitis]
M Duse1, R Merlini, R Gardenghi
1Clinica Pediatrica, Università degli Studi, Brescia.
Insights
Oxatomide effectively reduced itching and skin lesions in children with atopic dermatitis due to food allergies. The medication demonstrated good tolerability with no significant side effects observed.
Area of Science:
- Pediatric Dermatology
- Allergology
- Clinical Pharmacology
Background:
- Atopic dermatitis in children is often linked to food allergies.
- Diagnostic methods include prick tests, RAST, and challenge tests.
- Oxatomide is an antihistamine evaluated for this condition.
Purpose of the Study:
- To assess the efficacy of oxatomide in treating atopic dermatitis caused by alimentary allergy.
- To evaluate the tolerability of oxatomide in pediatric patients.
- To compare different dosing regimens of oxatomide.
Main Methods:
- A randomized study involving 40 children (6 months to 12 years) with atopic dermatitis.
- Two groups received oxatomide: one in a single evening dose, the other in two divided doses (1 mg/kg/day).
- Dosage could be increased to 2 mg/kg/day if therapeutic response was poor; symptom severity was monitored.
Main Results:
- Significant reduction in symptom severity within 15 days (p < 0.01).
- 28 children experienced significant improvement, with disappearance of lesions and itching.
- Eight children had fair itching control; five showed no substantial benefit. Tolerability was excellent, with one case of urticarial rash leading to treatment suspension.
Conclusions:
- Oxatomide is effective in controlling itching associated with food allergies in children.
- Efficacy is independent of the dosing schedule (single vs. divided doses).
- Oxatomide exhibits excellent tolerability with minimal adverse effects in pediatric patients.
Background:
This study evaluated the efficacy and tolerability of oxatomide in patients with atopic dermatitis, caused by alimentary allergy established by prick test and/or Rast and/or challenge test.
Methods:
In the study, carried out in a paediatric clinic, 40 children (24 males, 16 females), aged between 6 months and 12 years, were randomized in two groups. Twenty children were treated with oxatomide (1 mg/kg/day) in one evening dose and the other 20 were treated at the same dosage, divided into two administrations. In the case of poor therapeutic response, 15 days after the start of treatment, it was possible to double the dosage. The skin symptoms were monitored for the efficacy.
Results:
For all symptoms there was a significant reduction of severity within the fifteenth day (p < 0.01). Twenty eight children showed significant improvement with the disappearance of both cutaneous lesions and itching; to achieve these results in four cases (3 BID, 1 UID) it was necessary to double the dose (2 mg/kg/day). Eight children achieved a fair control of itching, with a slight improvement of eczema, while five children, despite the increase in dosage of the drug, did not get any substantial benefit. Three children were lost in follow-up, while in another case treatment was suspended because of the onset of an urticarious rash.
Conclusions:
The results confirm the efficacy of oxatomide in the control of itching connected with alimentary allergy independently of the posological scheme. Tolerability was excellent in both groups and no important side-effects were recorded.