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A study involving venlafaxine overdoses: comparison of fatal and therapeutic concentrations in postmortem specimens
P D Jaffe1, H P Batziris, P van der Hoeven
1Victorian Institute of Forensic Medicine, Monash University, Melbourne, Australia.
Journal of Forensic Sciences
|February 13, 1999
Abstract:
The distribution and redistribution of venlafaxine were investigated in two overdoses and several cases involving the therapeutic use of venlafaxine. Blood, liver, bile vitreous humor, urine and gastric contents were analyzed using high performance liquid chromatography with ultraviolet detection. Blood concentrations of venlafaxine in the two overdose cases were 53 mg/L and 78 mg/L. Comparison of venlafaxine concentrations in blood samples taken at different times after death revealed increases in concentrations over time, suggesting the possible postmortem redistribution of venlafaxine.