Cutaneous mucinoses and HIV infection

Area of Science:

• Dermatology
• Infectious Diseases
• Pathology

Background:

• Cutaneous mucinoses are increasingly reported in patients with human immunodeficiency virus (HIV).
• Understanding the association between mucin deposits and HIV infection is crucial for patient management.
• Previous literature shows a potential link, but specific mucinoses require further investigation in the context of HIV.

Observation:

• Three HIV-infected patients presented with distinct cutaneous mucinoses: scleredema, reticular erythematous mucinosis, and lichen myxoedematosus.
• This report details the first case of scleredema and the second case of reticular erythematous mucinosis in an HIV-infected individual.
• Clinical and histological findings were documented for each case.

Findings:

• The study highlights a potential increase in mucin deposition disorders among HIV patients.
• Scleredema and reticular erythematous mucinosis are rare manifestations in HIV-infected individuals.
• The association between HIV infection and lichen myxoedematosus suggests a possible pathogenetic link beyond mere coincidence.

Implications:

• These findings underscore the importance of dermatological surveillance in HIV-infected patients.
• Further research is warranted to elucidate the mechanisms underlying mucin deposition in HIV.
• Early recognition and management of these mucocutaneous manifestations may improve patient outcomes.