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Highly constrained dipeptoid analogues containing a type II' beta-turn mimic as novel and selective CCK-A receptor
N de la Figuera1, M Martín-Martínez, R Herranz
1Instituto de Química Médica (CSIC), Madrid, Spain.
Bioorganic & Medicinal Chemistry Letters
|February 17, 1999
Abstract:
Conformationally constrained dipeptoid analogues containing the type II' beta-turn mimic (2S,5s,11bR)-2-amino-3-oxohexahydroindolizino[8,7-b]indole-5 -carboxylate framework in place of the alpha-MeTrp residue, show high binding affinity and selectivity for CCK-A receptors, suggesting that a turn-like conformation could contribute to the bioactive conformation at this CCK receptor subtype.