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Chemmedchem|September 16, 2020
The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia DisordersChristoph Boss, John Gatfield, Christine Brotschi, et al.Chemmedchem|May 9, 2019
Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in RatsChristine Brotschi, Catherine Roch, John Gatfield, et al.Chemmedchem|January 17, 2020
From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in DogsChristine Brotschi, Martin H Bolli, John Gatfield, et al.The Journal of Pharmacology and Experimental Therapeutics|July 1, 2017
The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468Alexander Treiber, Ruben de Kanter, Catherine Roch, et al.Journal of Medicinal Chemistry|November 10, 2015
4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than ClopidogrelEva Caroff, Francis Hubler, Emmanuel Meyer, et al.Bioorganic & Medicinal Chemistry Letters|September 17, 2010
Piperidine-based renin inhibitors: upper chain optimizationOlivier Corminboeuf, Olivier Bezençon, Luboš Remeň, et al.Bioorganic & Medicinal Chemistry Letters|September 17, 2010
Design and optimization of new piperidines as renin inhibitorsOlivier Corminboeuf, Olivier Bezençon, Corinna Grisostomi, et al.Chemmedchem|July 9, 2016
Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping ApproachBibia Heidmann, John Gatfield, Catherine Roch, et al.The International Journal of Eating Disorders|March 8, 2024
Evaluating the efficacy of the selective orexin 1 receptor antagonist nivasorexant in an animal model of binge-eating disorderMichel Alexander Steiner, Luca Botticelli, Giorgio Bergamini, et al.Bioorganic & Medicinal Chemistry Letters|April 4, 2015
Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2Thierry Sifferlen, Amandine Boller, Audrey Chardonneau, et al.Pageof 5