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ACS Medicinal Chemistry Letters|June 6, 2014
Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided HybridizationJames E Dowling, Claudio Chuaqui, Timothy W Pontz, et al.Bioorganic & Medicinal Chemistry Letters|November 29, 2015
Identification of azabenzimidazoles as potent JAK1 selective inhibitorsMelissa M Vasbinder, Marat Alimzhanov, Martin Augustin, et al.Journal of Medicinal Chemistry|February 13, 2013
Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitorsMelissa M Vasbinder, Brian Aquila, Martin Augustin, et al.Blood|December 24, 2013
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemiaErika K Keeton, Kristen McEachern, Keith S Dillman, et al.Chemmedchem|December 22, 2017
Structure-Based Design of Selective Noncovalent CDK12 InhibitorsJeffrey W Johannes, Christopher R Denz, Nancy Su, et al.Journal of Medicinal Chemistry|April 17, 2020
Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 InhibitorQibin Su, Erica Banks, Geraldine Bebernitz, et al.Journal of Medicinal Chemistry|June 2, 2018
Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase InhibitorsNeil P Grimster, Erica Anderson, Marat Alimzhanov, et al.Bioorganic & Medicinal Chemistry Letters|June 3, 2023
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitorsNeil P Grimster, Lakshmaiah Gingipalli, Amber Balazs, et al.RSC Medicinal Chemistry|June 16, 2025
Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitorsAnthony J Metrano, Lucas A Morrill, Gayathri Bommakanti, et al.Journal of Medicinal Chemistry|February 10, 2025
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 InhibitorJason D Shields, David Baker, Amber Y S Balazs, et al.Pageof 3