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Organic Letters|June 3, 2010
Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometryBrian O Bachmann, Ruth McNees, Bruce J Melancon, et al.
Bioorganic & Medicinal Chemistry Letters|November 30, 2020
Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 4: SAR reveals positive cooperativity across multiple mGlu receptor subtypes leading to subtype unselective PAMsDexter C Davis, Joseph D Bungard, Sichen Chang, et al.
Biorxiv : the Preprint Server for Biology|August 30, 2023
Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitizationAlexa Strauss, Alberto J Gonzalez-Hernandez, Joon Lee, et al.
Bioorganic & Medicinal Chemistry Letters|August 30, 2021
Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compoundsYousuke Yamada, Kristen Gilliland, Zixiu Xiang, et al.
Bioorganic & Medicinal Chemistry Letters|February 19, 2013
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe moleculeMichael S Poslusney, Bruce J Melancon, Patrick R Gentry, et al.
Nature Communications|August 1, 2024
Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalizationAlexa Strauss, Alberto J Gonzalez-Hernandez, Joon Lee, et al.
Bioorganic & Medicinal Chemistry Letters|December 25, 2018
Novel M4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligandsMichael S Poslusney, James M Salovich, Michael R Wood, et al.
Plos Pathogens|July 19, 2011
A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptorsTasia M Pyburn, Barbara A Bensing, Yan Q Xiong, et al.
Bioorganic & Medicinal Chemistry Letters|July 4, 2012
Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012Bruce J Melancon, Thomas J Utley, Christian Sevel, et al.
Bioorganic & Medicinal Chemistry Letters|December 15, 2012
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe moleculeBruce J Melancon, Michael S Poslusney, Patrick R Gentry, et al.
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