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Dennis Colussi

Showing results (11-20 of 27) with videos related to

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Bioorganic & Medicinal Chemistry Letters|November 23, 2006
Beta-secretase (BACE-1) inhibitors: accounting for 10s loop flexibility using rigid active sitesGeorgia B McGaughey, Dennis Colussi, Samuel L Graham, et al.
Bioorganic & Medicinal Chemistry Letters|November 28, 2008
Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagementThomas G Steele, Ivory D Hills, Ashley A Nomland, et al.
Bioorganic & Medicinal Chemistry Letters|December 2, 2011
Discovery of pyrrolidine-based β-secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiencyShawn J Stachel, Thomas G Steele, Alessia Petrocchi, et al.
Bioorganic & Medicinal Chemistry Letters|July 31, 2009
A conformational constraint improves a beta-secretase inhibitor but for an unexpected reasonIvory D Hills, M Katharine Holloway, Pablo de León, et al.
Bioorganic & Medicinal Chemistry Letters|September 11, 2007
Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitorsKeith P Moore, Hong Zhu, Hemaka A Rajapakse, et al.
Bioorganic & Medicinal Chemistry Letters|February 4, 2010
Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitorsHong Zhu, Mary B Young, Philippe G Nantermet, et al.
Bioorganic & Medicinal Chemistry Letters|May 5, 2009
Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1Shawn J Stachel, Craig A Coburn, Diane Rush, et al.
Journal of Medicinal Chemistry|December 4, 2003
Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithromboticsJames C Barrow, Philippe G Nantermet, Shaun R Stauffer, et al.
Journal of Medicinal Chemistry|December 8, 2006
Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)Hemaka A Rajapakse, Philippe G Nantermet, Harold G Selnick, et al.
Journal of Medicinal Chemistry|June 23, 2007
Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloidMatthew G Stanton, Shaun R Stauffer, Alison R Gregro, et al.
Pageof 3

Showing results (11-20 of 27) with videos related to

Sort By:
Pageof 3
Bioorganic & Medicinal Chemistry Letters|November 23, 2006
Beta-secretase (BACE-1) inhibitors: accounting for 10s loop flexibility using rigid active sitesGeorgia B McGaughey, Dennis Colussi, Samuel L Graham, et al.
Bioorganic & Medicinal Chemistry Letters|November 28, 2008
Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagementThomas G Steele, Ivory D Hills, Ashley A Nomland, et al.
Bioorganic & Medicinal Chemistry Letters|December 2, 2011
Discovery of pyrrolidine-based β-secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiencyShawn J Stachel, Thomas G Steele, Alessia Petrocchi, et al.
Bioorganic & Medicinal Chemistry Letters|July 31, 2009
A conformational constraint improves a beta-secretase inhibitor but for an unexpected reasonIvory D Hills, M Katharine Holloway, Pablo de León, et al.
Bioorganic & Medicinal Chemistry Letters|September 11, 2007
Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitorsKeith P Moore, Hong Zhu, Hemaka A Rajapakse, et al.
Bioorganic & Medicinal Chemistry Letters|February 4, 2010
Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitorsHong Zhu, Mary B Young, Philippe G Nantermet, et al.
Bioorganic & Medicinal Chemistry Letters|May 5, 2009
Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1Shawn J Stachel, Craig A Coburn, Diane Rush, et al.
Journal of Medicinal Chemistry|December 4, 2003
Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithromboticsJames C Barrow, Philippe G Nantermet, Shaun R Stauffer, et al.
Journal of Medicinal Chemistry|December 8, 2006
Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)Hemaka A Rajapakse, Philippe G Nantermet, Harold G Selnick, et al.
Journal of Medicinal Chemistry|June 23, 2007
Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloidMatthew G Stanton, Shaun R Stauffer, Alison R Gregro, et al.
Pageof 3