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Blood|July 19, 2018
Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLLSean D Reiff, Elizabeth M Muhowski, Daphne Guinn, et al.
Bioorganic & Medicinal Chemistry Letters|July 15, 2014
Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonistsBenjamin P Fauber, Olivier René, Gladys de Leon Boenig, et al.
ACS Medicinal Chemistry Letters|March 28, 2015
Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of ActionOlivier René, Benjamin P Fauber, Gladys de Leon Boenig, et al.
Bioorganic & Medicinal Chemistry Letters|June 7, 2015
Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonistsBenjamin P Fauber, Alberto Gobbi, Kirk Robarge, et al.
Structure (London, England : 1993)|August 28, 2012
The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active siteGladys de Leon-Boenig, Krista K Bowman, Jianwen A Feng, et al.
ACS Medicinal Chemistry Letters|August 25, 2020
Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target ActivityJames J Crawford, Wendy Lee, Adam R Johnson, et al.
The Journal of Biological Chemistry|July 12, 2007
Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effectsAdam R Johnson, Alexander G Pavlovsky, Daniel F Ortwine, et al.
ACS Chemical Biology|August 30, 2016
Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 MutationsAdam R Johnson, Pawan Bir Kohli, Arna Katewa, et al.
The Journal of Pharmacology and Experimental Therapeutics|November 9, 2016
Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in RatsRebecca I Erickson, Leah K Schutt, Jacqueline M Tarrant, et al.
Science Translational Medicine|November 4, 2016
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunityCalliope A Dendrou, Adrian Cortes, Lydia Shipman, et al.
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