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International Journal of Pharmaceutics|March 9, 2026
Effect of electric charge on biotherapeutic transport, binding and absorption: A computational studyMario de Lucio, Pavlos P Vlachos, Hector Gomez
International Journal of Pharmaceutics|November 26, 2025
A computational framework for predicting leakage in subcutaneous injectionsMario de Lucio, Pavlos P Vlachos, Hector Gomez
International Journal of Pharmaceutics|July 12, 2024
Modeling drug transport and absorption in subcutaneous injection of monoclonal antibodies: Impact of tissue deformation, devices, and physiologyMario de Lucio, Yu Leng, Hao Wang, et al.
Biomechanics and Modeling in Mechanobiology|August 1, 2023
Computational modeling of the effect of skin pinch and stretch on subcutaneous injection of monoclonal antibodies using autoinjector devicesMario de Lucio, Yu Leng, Hao Wang, et al.
Advanced Drug Delivery Reviews|March 13, 2026
From molecule to absorption: a multiscale framework for subcutaneous biologic deliveryMario de Lucio, Vivek Sree, Galen Shi, et al.
Journal of the Mechanical Behavior of Biomedical Materials|December 18, 2022
Modeling large-volume subcutaneous injection of monoclonal antibodies with anisotropic porohyperelastic models and data-driven tissue layer geometriesMario de Lucio, Yu Leng, Atharva Hans, et al.
PNAS Nexus|January 30, 2023
Cavitation in a soft porous materialYu Leng, Pavlos P Vlachos, Ruben Juanes, et al.
Biomechanics and Modeling in Mechanobiology|September 3, 2022
Mixed-dimensional multi-scale poroelastic modeling of adipose tissue for subcutaneous injectionYu Leng, Hao Wang, Mario de Lucio, et al.
Drug Delivery|January 10, 2023
MPET<sup>2</sup>: a multi-network poroelastic and transport theory for predicting absorption of monoclonal antibodies delivered by subcutaneous injectionHao Wang, Tianyi Hu, Yu Leng, et al.
Computer Methods and Programs in Biomedicine|December 13, 2024
A MPET<sup>2</sup>-mPBPK model for subcutaneous injection of biotherapeutics with different molecular weights: From local scale to whole-body scaleHao Wang, Mario de Lucio, Tianyi Hu, et al.
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