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ACS Medicinal Chemistry Letters|June 20, 2020
Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence TimeAvinash Khanna, Alexandre Côté, Shilpi Arora, et al.
Science Advances|November 8, 2018
Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric gliomaJames M Stafford, Chul-Hwan Lee, Philipp Voigt, et al.
Biorxiv : the Preprint Server for Biology|May 25, 2026
Targeting an RNA Editor to Impede H3K27M+ Pediatric GliomasChristian K Ramsoomair, Victoria Alvarez, Felipe Sarmiento, et al.
Bioorganic & Medicinal Chemistry Letters|August 9, 2016
Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitorsSharada S Labadie, Peter S Dragovich, Richard T Cummings, et al.
Molecular Cell|August 8, 2025
Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during developmentRaghu Ram Edupuganti, Felipe Beckedorff, Pradeep Kumar Reddy Cingaram, et al.
Bioorganic & Medicinal Chemistry Letters|July 20, 2015
Discovery, design, and synthesis of indole-based EZH2 inhibitorsVictor S Gehling, Rishi G Vaswani, Christopher G Nasveschuk, et al.
The Journal of Clinical Investigation|June 24, 2025
BET inhibitors reduce tumor growth in preclinical models of gastrointestinal gene signature-positive castration-resistant prostate cancerShipra Shukla, Dan Li, Woo Hyun Cho, et al.
Bioorganic & Medicinal Chemistry Letters|August 2, 2016
Identification of potent, selective KDM5 inhibitorsVictor S Gehling, Steven F Bellon, Jean-Christophe Harmange, et al.
ACS Medicinal Chemistry Letters|June 20, 2020
Design and Synthesis of Styrenylcyclopropylamine LSD1 InhibitorsVictor S Gehling, John P McGrath, Martin Duplessis, et al.
Bioorganic & Medicinal Chemistry Letters|July 14, 2016
Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studiesJun Liang, Birong Zhang, Sharada Labadie, et al.
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