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Patrick Trojer

Showing results (41-50 of 55) with videos related to

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Chemistry & Biology|November 5, 2013
Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growthShivani Garapaty-Rao, Christopher Nasveschuk, Alexandre Gagnon, et al.
Plos One|November 23, 2016
An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 InhibitionBrian Egan, Chih-Chi Yuan, Madeleine Lisa Craske, et al.
The Journal of Biological Chemistry|February 1, 2021
Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activityJacob I Stuckey, Nico R Cantone, Alexandre Côté, et al.
ACS Medicinal Chemistry Letters|June 20, 2020
Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence TimeAvinash Khanna, Alexandre Côté, Shilpi Arora, et al.
Bioorganic & Medicinal Chemistry Letters|August 9, 2016
Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitorsSharada S Labadie, Peter S Dragovich, Richard T Cummings, et al.
Bioorganic & Medicinal Chemistry Letters|July 20, 2015
Discovery, design, and synthesis of indole-based EZH2 inhibitorsVictor S Gehling, Rishi G Vaswani, Christopher G Nasveschuk, et al.
The Journal of Clinical Investigation|June 24, 2025
BET inhibitors reduce tumor growth in preclinical models of gastrointestinal gene signature-positive castration-resistant prostate cancerShipra Shukla, Dan Li, Woo Hyun Cho, et al.
Bioorganic & Medicinal Chemistry Letters|August 2, 2016
Identification of potent, selective KDM5 inhibitorsVictor S Gehling, Steven F Bellon, Jean-Christophe Harmange, et al.
ACS Medicinal Chemistry Letters|June 20, 2020
Design and Synthesis of Styrenylcyclopropylamine LSD1 InhibitorsVictor S Gehling, John P McGrath, Martin Duplessis, et al.
Bioorganic & Medicinal Chemistry Letters|July 14, 2016
Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studiesJun Liang, Birong Zhang, Sharada Labadie, et al.
Pageof 6

Showing results (41-50 of 55) with videos related to

Sort By:
Pageof 6
Chemistry & Biology|November 5, 2013
Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growthShivani Garapaty-Rao, Christopher Nasveschuk, Alexandre Gagnon, et al.
Plos One|November 23, 2016
An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 InhibitionBrian Egan, Chih-Chi Yuan, Madeleine Lisa Craske, et al.
The Journal of Biological Chemistry|February 1, 2021
Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activityJacob I Stuckey, Nico R Cantone, Alexandre Côté, et al.
ACS Medicinal Chemistry Letters|June 20, 2020
Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence TimeAvinash Khanna, Alexandre Côté, Shilpi Arora, et al.
Bioorganic & Medicinal Chemistry Letters|August 9, 2016
Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitorsSharada S Labadie, Peter S Dragovich, Richard T Cummings, et al.
Bioorganic & Medicinal Chemistry Letters|July 20, 2015
Discovery, design, and synthesis of indole-based EZH2 inhibitorsVictor S Gehling, Rishi G Vaswani, Christopher G Nasveschuk, et al.
The Journal of Clinical Investigation|June 24, 2025
BET inhibitors reduce tumor growth in preclinical models of gastrointestinal gene signature-positive castration-resistant prostate cancerShipra Shukla, Dan Li, Woo Hyun Cho, et al.
Bioorganic & Medicinal Chemistry Letters|August 2, 2016
Identification of potent, selective KDM5 inhibitorsVictor S Gehling, Steven F Bellon, Jean-Christophe Harmange, et al.
ACS Medicinal Chemistry Letters|June 20, 2020
Design and Synthesis of Styrenylcyclopropylamine LSD1 InhibitorsVictor S Gehling, John P McGrath, Martin Duplessis, et al.
Bioorganic & Medicinal Chemistry Letters|July 14, 2016
Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studiesJun Liang, Birong Zhang, Sharada Labadie, et al.
Pageof 6