Rainer Machauer

5PUBLICATIONS
21CO-AUTHORS
Proteins and peptidesMolecular targetsCheminformatics and quantitative structure-activity relationshipsBiomolecular modelling and design
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Publications (5)

|Oct 15, 2025
Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement.

Juraj Velcicky, Jean-Baptiste Langlois, Michael Wright

|Jun 27, 2025
Discovery and Optimization of Selective Inhibitors of Large Tumor Suppressor Kinases LATS1 and 2 for In Vivo Investigation of the Hippo-YAP Pathway in Tissue Regeneration.

Kenji Namoto, Eric Vangrevelinghe, Rainer Machauer

|Nov 18, 2022
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors.

Edwige Lorthiois, Marc Gerspacher, Kim S Beyer

|Oct 14, 2021
Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease.

Rainer Machauer, Rainer Lueoend, Konstanze Hurth

|Apr 12, 2021
Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360.

Heinrich Rueeger, Rainer Lueoend, Rainer Machauer

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Frequent Collaborators

1 joint publications

Edwige Lorthiois

1 joint publications

Kim S Beyer

1 joint publications

Andrea Vaupel

1 joint publications

Rowan Stringer