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Rainer Machauer

5PUBLICATIONS

21CO-AUTHORS

Proteins and peptidesMolecular targetsCheminformatics and quantitative structure-activity relationshipsBiomolecular modelling and design

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Publications (5)

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|Oct 15, 2025

Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement.

Juraj Velcicky, Jean-Baptiste Langlois, Michael Wright

|Jun 27, 2025

Discovery and Optimization of Selective Inhibitors of Large Tumor Suppressor Kinases LATS1 and 2 for In Vivo Investigation of the Hippo-YAP Pathway in Tissue Regeneration.

Kenji Namoto, Eric Vangrevelinghe, Rainer Machauer

|Nov 18, 2022

JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS<sup>G12C</sup> for the Treatment of Solid Tumors.

Edwige Lorthiois, Marc Gerspacher, Kim S Beyer

|Oct 14, 2021

Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease.

Rainer Machauer, Rainer Lueoend, Konstanze Hurth

|Apr 12, 2021

Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360.

Heinrich Rueeger, Rainer Lueoend, Rainer Machauer

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Frequent Collaborators

1 joint publications

Edwige Lorthiois

1 joint publications

Kim S Beyer

1 joint publications

Andrea Vaupel

1 joint publications

Rowan Stringer

1 joint publications

Andreas Weiss

1 joint publications

Rainer Wilcken

1 joint publications

Daniel A Guthy

1 joint publications

Andreas Lingel

1 joint publications

Claudio Bomio-Confaglia

1 joint publications

Johannes Ottl

Frequent Collaborators

1 joint publications

Edwige Lorthiois

1 joint publications

Kim S Beyer

1 joint publications

Andrea Vaupel

1 joint publications

Rowan Stringer

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