Rainer Wilcken

10PUBLICATIONS
57CO-AUTHORS
Biomolecular modelling and designMolecular targetsProteomics and intermolecular interactions (excl. medical proteomics)Electrochemical energy storage and conversionComputational chemistry
Featured researcher

Get your video featured.

JoVEPublish with JoVE
Journal

Publications (10)

|May 19, 2026
Targeting Multiple KRAS Mutations with High-Affinity Macrocyclic Inhibitors: From Discovery to Preclinical Validation.

|Dec 09, 2025
Fragment-based discovery enables direct targeting of the melanoma oncogene MITF.

Deborah Castelletti, Jürgen Hinrichs, Goran Malojčić

|Jul 10, 2025
Promise and Challenge of β-Lactone Electrophiles to Target Aspartate 12 of Mutant KRAS<sup>G12D</sup>.

Balázs Budai, Andrea Vaupel, Callum J Dickson

|Dec 12, 2024
Dynamic conformational equilibria in the active states of KRAS and NRAS.

Enrico Rennella, Chrystèle Henry, Callum J Dickson

|Nov 18, 2022
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS<sup>G12C</sup> for the Treatment of Solid Tumors.

Edwige Lorthiois, Marc Gerspacher, Kim S Beyer

|Apr 11, 2022
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.

Andreas Weiss, Edwige Lorthiois, Louise Barys

Pageof 2

Frequent Collaborators

5 joint publications

Kim S Beyer

4 joint publications

Simona Cotesta

4 joint publications

Nils Ostermann

3 joint publications

Andrea Vaupel