Rainer Wilcken

11PUBLICATIONS
60CO-AUTHORS
Cancer geneticsBiomolecular modelling and designMolecular targetsProteomics and intermolecular interactions (excl. medical proteomics)Electrochemical energy storage and conversion
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Publications (11)

|Oct 23, 2026
Thermodynamic Insights into the WT and Y220C TP53 DBDs Reveal that the Oncogenic Y220C Variant is a Loss-of-Function Mutation for Zn2+-Binding at Physiological Temperature.

|May 19, 2026
Targeting Multiple KRAS Mutations with High-Affinity Macrocyclic Inhibitors: From Discovery to Preclinical Validation.

|Dec 09, 2025
Fragment-based discovery enables direct targeting of the melanoma oncogene MITF.

Deborah Castelletti, Jürgen Hinrichs, Goran Malojčić

|Jul 10, 2025
Promise and Challenge of β-Lactone Electrophiles to Target Aspartate 12 of Mutant KRASG12D.

Balázs Budai, Andrea Vaupel, Callum J Dickson

|Dec 12, 2024
Dynamic conformational equilibria in the active states of KRAS and NRAS.

Enrico Rennella, Chrystèle Henry, Callum J Dickson

|Nov 18, 2022
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors.

Edwige Lorthiois, Marc Gerspacher, Kim S Beyer

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Frequent Collaborators

5 joint publications

Kim S Beyer

4 joint publications

Simona Cotesta

4 joint publications

Nils Ostermann

3 joint publications

Andrea Vaupel