Christopher R Brown

5PUBLICATIONS
11CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsGlycoconjugatesBiologically active molecules
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Publications (5)

|Dec 10, 2024
High resistance barrier and prophylactic protection in preclinical models of SARS-CoV-2 with two siRNA combination.

Yesseinia I Anglero-Rodriguez, Florian A Lempp, Megha Subramanian

|Jun 23, 2022
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.

Mark K Schlegel, Maja M Janas, Yongfeng Jiang

|Oct 14, 2021
Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.

Mark K Schlegel, Shigeo Matsuda, Christopher R Brown

|Sep 11, 2021
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.

Hartmut Jahns, Rohan Degaonkar, Peter Podbevsek

|Jul 16, 2021
Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo.

Hartmut Jahns, Nate Taneja, Jennifer L S Willoughby

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