Mark K Schlegel

15PUBLICATIONS
41CO-AUTHORS
GlycoconjugatesMicro- and nanosystemsMedical devicesBiologically active moleculesCheminformatics and quantitative structure-activity relationships
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Publications (15)

|Apr 17, 2026
Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.

|Sep 29, 2025
Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAs.

Shohei Mori, Dhrubajyoti Datta, Lydia Perkins

|Feb 12, 2025
In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.

Marco De Giorgi, So Hyun Park, Adam Castoreno

|Feb 03, 2025
Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3' End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain.

Rajat S Das, Dhrubajyoti Datta, Christopher R Brown

|Dec 10, 2024
High resistance barrier and prophylactic protection in preclinical models of SARS-CoV-2 with two siRNA combination.

Yesseinia I Anglero-Rodriguez, Florian A Lempp, Megha Subramanian

|Aug 28, 2023
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.

Shigeo Matsuda, Saikat Bala, Jen-Yu Liao

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Frequent Collaborators

10 joint publications

Muthiah Manoharan

9 joint publications

Martin Egli

6 joint publications

Vasant Jadhav

5 joint publications

Ivan Zlatev