Hiroaki Mitsuya

17PUBLICATIONS
60CO-AUTHORS
Biomolecular modelling and designBiologically active moleculesGenetic immunologyCheminformatics and quantitative structure-activity relationshipsRegenerative medicine (incl. stem cells)
Featured researcher

Get your video featured.

JoVEPublish with JoVE
Journal

Publications (17)

|Jun 30, 2026
Design, synthesis, and X-ray structural studies of potent SARS-CoV-2 Mpro inhibitors containing tetrahydroisoquinoline-3-carboxamides as P2 ligands.

|Jan 20, 2025
An orally available P1'-5-fluorinated Mpro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier.

Nobuyo Higashi-Kuwata, Haydar Bulut, Hironori Hayashi

|Jul 12, 2023
GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants.

Manabu Aoki, Hiromi Aoki-Ogata, Haydar Bulut

|Feb 25, 2023
Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2.

Nobuyo Higashi-Kuwata, Kohei Tsuji, Hironori Hayashi

|Oct 31, 2022
Generation of Angiotensin-Converting Enzyme 2/Transmembrane Protease Serine 2-Double-Positive Human Induced Pluripotent Stem Cell-Derived Spheroids for Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Drug Evaluation.

Nobuyo Higashi-Kuwata, Shigeharu G Yabe, Satsuki Fukuda

|Oct 11, 2022
SARS-CoV-2-Neutralizing Humoral IgA Response Occurs Earlier but Is Modest and Diminishes Faster than IgG Response.

Yuki Takamatsu, Kazumi Omata, Yosuke Shimizu

Pageof 3

Frequent Collaborators

8 joint publications

Yuki Takamatsu

7 joint publications

Shin-Ichiro Hattori

6 joint publications

Nobuyo Higashi-Kuwata

5 joint publications

Debananda Das