Nobuyo Higashi-Kuwata

9PUBLICATIONS
40CO-AUTHORS
Biomolecular modelling and designCheminformatics and quantitative structure-activity relationshipsBiologically active moleculesGenetic immunologyRegenerative medicine (incl. stem cells)
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Publications (9)

|Jun 30, 2026
Design, synthesis, and X-ray structural studies of potent SARS-CoV-2 Mpro inhibitors containing tetrahydroisoquinoline-3-carboxamides as P2 ligands.

|Feb 02, 2026
Impact of Single Halogen Atom Substitutions on Antiviral Profile of Inhibitors Targeting SARS-CoV‑2 Main Protease.

Haydar Bulut, Nobuyo Higashi-Kuwata, Hiromi Ogata-Aoki

|Sep 22, 2025
SARS-CoV‑2 Main Protease Inhibitors Containing 5‑Substituted Benzothiazole-2-carbonyl Moieties at the P1' Site and Their Derivatives.

Kohei Tsuji, Takuya Kobayakawa, Nobuyo Higashi-Kuwata

|Jan 20, 2025
An orally available P1'-5-fluorinated Mpro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier.

Nobuyo Higashi-Kuwata, Haydar Bulut, Hironori Hayashi

|Jul 12, 2023
GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants.

Manabu Aoki, Hiromi Aoki-Ogata, Haydar Bulut

|Jun 02, 2023
Synthesis of novel entecavir analogues having 4'-cyano-6''-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent.

Hiroki Kumamoto, Nobuyo Higashi-Kuwata, Sanae Hayashi

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Frequent Collaborators

6 joint publications

Hiroaki Mitsuya

5 joint publications

Shin-Ichiro Hattori

5 joint publications

Haydar Bulut

5 joint publications

Debananda Das