Changho Han

10PUBLICATIONS
20CO-AUTHORS
Biomolecular modelling and designPharmaceutical delivery technologiesCharacterisation of biological macromoleculesMolecular targetsCheminformatics and quantitative structure-activity relationships
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Publications (10)

|Sep 15, 2026
De Novo Design in an M1 Positive Allosteric Modulator Backup Program: The Discovery of VU6069863.

|Jul 16, 2025
Discovery of a Novel sp3‑Rich M1 Positive Allosteric Modulators (PAMs) Chemotype via Scaffold Hopping.

Joseph D Bungard, Paul Spearing, Yu Nishio

|May 14, 2025
Discovery of Thieno[3,2-b]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5.

Katherine E Crocker, Scott H Henderson, Rory A Capstick

|Mar 25, 2025
Application of Deuterium in an M1 Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422.

Julie L Engers, Jinming Li, Changho Han

|Dec 11, 2024
Discovery of VU0467319: an M1 Positive Allosteric Modulator Candidate That Advanced into Clinical Trials.

Michael S Poslunsey, Michael R Wood, Changho Han

|Aug 06, 2024
Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine Receptor.

Jinming Li, Douglas L Orsi, Julie L Engers

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Frequent Collaborators

9 joint publications

Craig W Lindsley

6 joint publications

Alice L Rodriguez

5 joint publications

Julie L Engers

2 joint publications

Douglas L Orsi