Zixiu Xiang

8PUBLICATIONS
23CO-AUTHORS
Biomolecular modelling and designCharacterisation of biological macromoleculesPharmaceutical delivery technologiesGlycoconjugatesMedical molecular engineering of nucleic acids and proteins
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Publications (8)

|Jun 06, 2026
Discovery of VU6053371/BI03738809: A First-in-Class Selective and CNS-Penetrant mGlu3 Positive Allosteric Modulator (PAM) with Efficacy in a Preclinical Cognition Model.

|Jul 21, 2025
Profiling the Impact of mGlu7/Elfn1 Protein Interactions on the Pharmacology of mGlu7 Allosteric Modulators.

Xia Lei, Zixiu Xiang, Alice L Rodriguez

|Mar 25, 2025
Application of Deuterium in an M1 Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422.

Julie L Engers, Jinming Li, Changho Han

|Apr 07, 2021
Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu2/mGlu4 receptor heterodimers.

Zixiu Xiang, Xiaohui Lv, Xin Lin

|Dec 05, 2019
Biased M1 receptor-positive allosteric modulators reveal role of phospholipase D in M1-dependent rodent cortical plasticity.

Sean P Moran, Zixiu Xiang, Catherine A Doyle

|Mar 28, 2018
M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition.

Sean P Moran, Jonathan W Dickerson, Hyekyung P Cho

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Frequent Collaborators

5 joint publications

Colleen M Niswender

4 joint publications

Craig W Lindsley

3 joint publications

P Jeffrey Conn

2 joint publications

Nicole M Fisher