Paolo Di Fruscia

4PUBLICATIONS
22CO-AUTHORS
Molecular targetsCheminformatics and quantitative structure-activity relationshipsBiomolecular modelling and designBiologically active molecules
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Publications (4)

|Oct 15, 2025
Focused Structure-Based Virtual Screening Identifies Novel Inhibitors of SOS1.

Silvia Bonomo, Floriane Gibault, Sharan K Bagal

|Dec 10, 2024
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor.

Jeffrey W Johannes, Amber Y S Balazs, Derek Barratt

|Sep 27, 2021
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.

Jeffrey W Johannes, Amber Balazs, Derek Barratt

|Sep 01, 2021
Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration.

Paolo Di Fruscia, Anna Carbone, Giovanni Bottegoni

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Frequent Collaborators

2 joint publications

Jeffrey W Johannes

2 joint publications

Avipsa Ghosh

2 joint publications

Marianne Schimpl

2 joint publications

Andrew X Zhang