Marianne Schimpl

18PUBLICATIONS
64CO-AUTHORS
Evolutionary computationMolecular targetsCheminformatics and quantitative structure-activity relationshipsBiologically active moleculesBiomolecular modelling and design
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Publications (18)

|Jul 21, 2026
Generative AI-Assisted Discovery of HPK1 Inhibitors.

|Dec 29, 2025
Genetic evidence for PARP1 trapping as a driver of PARP inhibitor efficacy in BRCA mutant cancer cells.

Jonathan Ribeiro, Kjetil Hansen, Lotte van Beek

|Jun 18, 2025
Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders.

Jeffrey A Boerth, Marianne Schimpl, Simon C C Lucas

|Jun 16, 2025
Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors.

Anthony J Metrano, Lucas A Morrill, Gayathri Bommakanti

|Feb 10, 2025
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor.

Jason D Shields, David Baker, Amber Y S Balazs

|Dec 10, 2024
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor.

Jeffrey W Johannes, Amber Y S Balazs, Derek Barratt

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Frequent Collaborators

6 joint publications

Neil P Grimster

4 joint publications

Jeffrey A Boerth

4 joint publications

Andrew X Zhang

4 joint publications

Graeme Robb