Marianne Schimpl

17PUBLICATIONS
62CO-AUTHORS
Molecular targetsCheminformatics and quantitative structure-activity relationshipsBiologically active moleculesBiomolecular modelling and designApplied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)
Featured researcher

Get your video featured.

JoVEPublish with JoVE
Journal

Publications (17)

|Dec 29, 2025
Genetic evidence for PARP1 trapping as a driver of PARP inhibitor efficacy in BRCA mutant cancer cells.

Jonathan Ribeiro, Kjetil Hansen, Lotte van Beek

|Jun 18, 2025
Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders.

Jeffrey A Boerth, Marianne Schimpl, Simon C C Lucas

|Jun 16, 2025
Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors.

Anthony J Metrano, Lucas A Morrill, Gayathri Bommakanti

|Feb 10, 2025
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor.

Jason D Shields, David Baker, Amber Y S Balazs

|Dec 10, 2024
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-<i>N</i>-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor.

Jeffrey W Johannes, Amber Y S Balazs, Derek Barratt

|Aug 12, 2024
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design.

Taylor R Quinn, Kathryn A Giblin, Clare Thomson

Pageof 3

Frequent Collaborators

5 joint publications

Neil P Grimster

4 joint publications

Jeffrey A Boerth

4 joint publications

Andrew X Zhang

4 joint publications

Graeme Robb