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Phil B Alper

5PUBLICATIONS
14CO-AUTHORS
Biomolecular modelling and designInnate immunityAutoimmunityNatural products and bioactive compoundsMolecular targets
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Journal

Publications (5)

Sort by Publication Date:
|May 19, 2026
Targeting Multiple KRAS Mutations with High-Affinity Macrocyclic Inhibitors: From Discovery to Preclinical Validation.

|Aug 16, 2023
Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases.

Phil Alper, Claudia Betschart, Cédric André

|Aug 14, 2020
Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.

Thomas Knoepfel, Pierre Nimsgern, Sébastien Jacquier

|Dec 22, 2017
Photoinduced Rearrangement of Dienones and Santonin Rerouted by Amines.

Zhipeng Zhang, Maxim Ratnikov, Glen Spraggon

|Nov 18, 2017
Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).

David C Tully, Paul V Rucker, Donatella Chianelli

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Frequent Collaborators

2 joint publications

Thomas Knoepfel

1 joint publications

Claudia Betschart

1 joint publications

David C Tully

1 joint publications

Zhipeng Zhang

1 joint publications

Maxim Ratnikov

1 joint publications

Glen Spraggon

1 joint publications

Dean P Phillips

1 joint publications

Sarah E Kochanek

1 joint publications

Michael DiDonato

1 joint publications

Angela Bretz

Frequent Collaborators

2 joint publications

Thomas Knoepfel

1 joint publications

Claudia Betschart

1 joint publications

David C Tully

1 joint publications

Zhipeng Zhang