Matthew S Dowling

10PUBLICATIONS
50CO-AUTHORS
Gene and molecular therapyBiomolecular modelling and designCatalysis and mechanisms of reactionsBiologically active moleculesCharacterisation of biological macromolecules
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Publications (10)

|Oct 23, 2026
Discovery of Neutral and Cerebrospinal Fluid Penetrant Transthyretin (TTR) Stabilizers with Heterocyclic Linkers.

|Mar 22, 2024
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex.

Aliakbar Khalili Yazdi, Sumera Perveen, Cheng Dong

|Aug 23, 2023
Decarboxylative Cross-Electrophile Coupling of (Hetero)Aromatic Bromides and NHP Esters.

Ethan M DeCicco, Simon Berritt, Thomas Knauber

|May 06, 2023
Mitigating a Bioactivation Liability with an Azetidine-Based Inhibitor of Diacylglycerol Acyltransferase 2 (DGAT2) En Route to the Discovery of the Clinical Candidate Ervogastat.

Raman Sharma, Matthew S Dowling, Kentaro Futatsugi

|Apr 28, 2023
Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells.

Jordan M Mattheisen, Chris Limberakis, Roger B Ruggeri

|Dec 23, 2022
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

Allyn T Londregan, Karlygash Aitmakhanova, James Bennett

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Frequent Collaborators

5 joint publications

Amit S Kalgutkar

2 joint publications

Aaron C Smith

2 joint publications

Dafydd R Owen

2 joint publications

Chris Limberakis