Steven T Staben

7PUBLICATIONS
12CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsBiomolecular modelling and designBiologically active moleculesProteins and peptidesIndustrial molecular engineering of nucleic acids and proteins
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Publications (7)

|Dec 01, 2022
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.

Emily J Hanan, Marie-Gabrielle Braun, Robert A Heald

|Oct 24, 2022
Overcoming Preclinical Safety Obstacles to Discover (<i>S</i>)-<i>N</i>-((1,2,3,5,6,7-Hexahydro-<i>s</i>-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5<i>H</i>-pyrazolo[5,1-<i>b</i>][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.

Christopher McBride, Lynnie Trzoss, Davide Povero

|Jul 08, 2021
Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein.

Willem den Besten, Kshitij Verma, Sayumi Yamazoe

|May 01, 2020
Monomeric Targeted Protein Degraders.

Emily J Hanan, Jun Liang, Xiaojing Wang

|Mar 07, 2020
Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases.

Nicole Blaquiere, Elisia Villemure, Steven T Staben

|Dec 25, 2019
Heterobifunctional Molecules Induce Dephosphorylation of Kinases-A Proof of Concept Study.

Sayumi Yamazoe, Jeffrey Tom, Yue Fu

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Frequent Collaborators

1 joint publications

James J Crawford

1 joint publications

Kshitij Verma

1 joint publications

Erin Dueber

1 joint publications

Wayne J Fairbrother