Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

R Scott Obach

10PUBLICATIONS

55CO-AUTHORS

Medical biochemistry - nucleic acidsPharmaceutical delivery technologiesInfectious diseasesToxicology (incl. clinical toxicology)Proteins and peptides

Featured researcher

Get your video featured.

Publish with JoVE

Featured researcher

Get your video featured.

Publish with JoVE

Publications (10)

Sort by Publication Date:

|Jun 09, 2022

Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development.

Ravi Shankar P Singh, Gregory S Walker, Eugene P Kadar

|Feb 14, 2022

Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans.

Heather Eng, Alyssa L Dantonio, Eugene P Kadar

|Nov 02, 2021

An oral SARS-CoV-2 M<sup>pro</sup> inhibitor clinical candidate for the treatment of COVID-19.

Dafydd R Owen, Charlotte M N Allerton, Annaliesa S Anderson

|Jul 30, 2021

Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes.

Elaine Tseng, Heather Eng, Jian Lin

|Apr 03, 2021

Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants.

Heather Eng, Elaine Tseng, Matthew A Cerny

|Sep 16, 2020

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19.

Britton Boras, Rhys M Jones, Brandon J Anson

Pageof 2

Frequent Collaborators

6 joint publications

Heather Eng

3 joint publications

Ravi Shankar P Singh

3 joint publications

Amit S Kalgutkar

2 joint publications

Emi Kimoto

2 joint publications

Eugene P Kadar

2 joint publications

Dafydd R Owen

2 joint publications

Li Di

2 joint publications

Theunis C Goosen

2 joint publications

Claire Steppan

2 joint publications

Britton Boras

Frequent Collaborators

6 joint publications

Heather Eng

3 joint publications

Ravi Shankar P Singh

3 joint publications

Amit S Kalgutkar

2 joint publications

Emi Kimoto

Top Related Videos

Application and Methodology of the Non-destructive <sup>19</sup>F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Application and Methodology of the Non-destructive <sup>19</sup>F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Published on : Aug 22, 2017

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on : May 09, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on : Nov 05, 2021

See more related videos

Top Related Videos

Application and Methodology of the Non-destructive <sup>19</sup>F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Application and Methodology of the Non-destructive <sup>19</sup>F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Published on : Aug 22, 2017

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on : May 09, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on : Nov 05, 2021

See more related videos