Tom D Heightman

10PUBLICATIONS
23CO-AUTHORS
Molecular medicineCheminformatics and quantitative structure-activity relationshipsBiologically active moleculesProteins and peptidesBiomolecular modelling and design
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Publications (10)

|Sep 10, 2026
The Discovery of GSK3227634: A Potent Inhaled Inhibitor of the KEAP1/NRF2 Protein-Protein Interaction for the Treatment of Chronic Obstructive Pulmonary Disease.

|Dec 10, 2024
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor.

Jeffrey W Johannes, Amber Y S Balazs, Derek Barratt

|Oct 20, 2022
Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.

Emiliano Tamanini, Shin Miyamura, Ildiko M Buck

|Apr 12, 2019
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.

Tom D Heightman, James F Callahan, Elisabetta Chiarparin

|Mar 19, 2019
Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines.

Rachel Grainger, Tom D Heightman, Steven V Ley

|Dec 21, 2018
Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe.

Honorine Lebraud, Olga Surova, Aurélie Courtin

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Frequent Collaborators

4 joint publications

Alison J-A Woolford

2 joint publications

Emiliano Tamanini

2 joint publications

Jeffrey K Kerns

2 joint publications

Thomas G Davies