Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Tom D Heightman

9PUBLICATIONS

21CO-AUTHORS

Cheminformatics and quantitative structure-activity relationshipsBiologically active moleculesProteins and peptidesBiomolecular modelling and designMolecular targets

Featured researcher

Get your video featured.

Publish with JoVE

Featured researcher

Get your video featured.

Publish with JoVE

Publications (9)

Sort by Publication Date:

|Dec 10, 2024

Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-<i>N</i>-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor.

Jeffrey W Johannes, Amber Y S Balazs, Derek Barratt

|Oct 20, 2022

Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.

Emiliano Tamanini, Shin Miyamura, Ildiko M Buck

|Apr 12, 2019

Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.

Tom D Heightman, James F Callahan, Elisabetta Chiarparin

|Mar 19, 2019

Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines.

Rachel Grainger, Tom D Heightman, Steven V Ley

|Dec 21, 2018

Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe.

Honorine Lebraud, Olga Surova, Aurélie Courtin

|Jun 01, 2018

Highly Potent Clickable Probe for Cellular Imaging of MDM2 and Assessing Dynamic Responses to MDM2-p53 Inhibition.

Honorine Lebraud, Richard A Noble, Nicole Phillips

Pageof 2

Frequent Collaborators

3 joint publications

Alison J-A Woolford

2 joint publications

Emiliano Tamanini

1 joint publications

Rachel Grainger

1 joint publications

Steven V Ley

1 joint publications

Fabio Lima

1 joint publications

Christopher N Johnson

1 joint publications

Paul N Mortenson

1 joint publications

Henriëtte M G Willems

1 joint publications

Jeffrey K Kerns

1 joint publications

Thomas G Davies

Frequent Collaborators

3 joint publications

Alison J-A Woolford

2 joint publications

Emiliano Tamanini

1 joint publications

Rachel Grainger

1 joint publications

Steven V Ley

Top Related Videos

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Published on : Aug 21, 2013

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS

Published on : Aug 10, 2017

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on : Jul 16, 2017

See more related videos

Top Related Videos

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Published on : Aug 21, 2013

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS

Published on : Aug 10, 2017

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on : Jul 16, 2017

See more related videos