Alison J-A Woolford

9PUBLICATIONS
23CO-AUTHORS
Molecular medicineF-block chemistryCheminformatics and quantitative structure-activity relationshipsBiologically active moleculesMolecular targets
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Publications (9)

|Sep 10, 2026
The Discovery of GSK3227634: A Potent Inhaled Inhibitor of the KEAP1/NRF2 Protein-Protein Interaction for the Treatment of Chronic Obstructive Pulmonary Disease.

|Oct 03, 2025
Design, modular synthesis and screening of 58 shape-diverse 3-D fragments.

Thomas D Downes, S Paul Jones, James D Firth

|Dec 22, 2022
Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates.

S Paul Jones, James D Firth, Mary C Wheldon

|Oct 20, 2022
Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.

Emiliano Tamanini, Shin Miyamura, Ildiko M Buck

|Oct 27, 2021
Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.

David Norton, William G Bonnette, James F Callahan

|Aug 13, 2021
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.

Tom D Heightman, Valerio Berdini, Luke Bevan

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Frequent Collaborators

4 joint publications

Tom D Heightman

3 joint publications

Jeffrey K Kerns

3 joint publications

Thomas G Davies

2 joint publications

Henriëtte M G Willems