Nicholas McHugh

5PUBLICATIONS
31CO-AUTHORS
Gene and molecular therapyBiologically active moleculesMedical molecular engineering of nucleic acids and proteins
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Publications (5)

|Jul 21, 2026
Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality in an MECP2 duplication mouse model.

|May 02, 2025
Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model.

Vignesh N Hariharan, Ashley Summers, Amy E Clipperton-Allen

|Aug 01, 2024
Enhancing siRNA efficacy in vivo with extended nucleic acid backbones.

Ken Yamada, Vignesh N Hariharan, Jillian Caiazzi

|Nov 05, 2023
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin.

Qi Tang, Hassan H Fakih, Mohammad Zain Ui Abideen

|Jul 03, 2023
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo.

Vignesh Narayan Hariharan, Jillian Caiazzi, Rachael Miller

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Frequent Collaborators

5 joint publications

Vignesh Narayan Hariharan

5 joint publications

Qi Tang

5 joint publications

Ashley Summers

5 joint publications

Anastasia Khvorova