Paul K Fyfe

6PUBLICATIONS
34CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsInnate immunityMolecular targetsApplied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)
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Publications (6)

|Mar 07, 2024
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency.

Scott Gardner, Yibo Jin, Paul K Fyfe

|Dec 02, 2022
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.

Silvia Gaggero, Jonathan Martinez-Fabregas, Adeline Cozzani

|Aug 03, 2022
Structural insights into the assembly and activation of the IL-27 signaling complex.

Yibo Jin, Paul K Fyfe, Scott Gardner

|Apr 19, 2021
Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses.

Stephan Wilmes, Polly-Anne Jeffrey, Jonathan Martinez-Fabregas

|Sep 16, 2020
Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses.

Claire Gorby, Junel Sotolongo Bellón, Stephan Wilmes

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