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Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

[Primary glomerulopathies: incidence, dynamics and clinical manifestations of morphological variants]

B R Dzhanaliev1, V A Varshavskiĭ, A A Laurinavichus

  • 1I.M. Sechenov Moscow Medical Academy, 119881, Moscow.

Arkhiv Patologii
|July 11, 2002
PubMed

Insights

Primary glomerulopathy (PGP) affects over 60% of kidney biopsies. Non-inflammatory PGP types increased, while hematuric forms like mesangioproliferative glomerulonephritis decreased in relative frequency over 30 years.

Area of Science:

  • Nephrology
  • Pathology
  • Immunopathology

Context:

  • Analysis of 4400 kidney biopsies from I.M. Sechenov Moscow Medical Academy (1970-1999).
  • Focus on the etiological spectrum and temporal trends of primary glomerulopathies (PGP).

Purpose:

  • To investigate the prevalence and changing patterns of different types of primary glomerulopathy.
  • To correlate specific PGP subtypes with clinical presentations (nephrotic vs. hematuric).

Summary:

  • Primary glomerulopathy (PGP) was diagnosed in 62.4% of biopsies.
  • Mesangioproliferative glomerulonephritis (MPGN) was the most common type (48.9%), often presenting with hematuria.
  • Minimal changes (MC), membranous nephropathy (MN), and focal segmentary glomerulosclerosis/hyalinosis (FSGH) were primarily of nephrotic origin.
  • A significant trend observed was the increasing relative frequency of non-inflammatory PGP variants (MC, MN, FSGH) and a decrease in hematuric variants (MPGN, MCGN) over the study period.

Impact:

  • Highlights evolving epidemiological trends in glomerular diseases.
  • Provides insights into the changing landscape of kidney pathology.
  • Informs clinical management and research priorities for glomerulonephritis.

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