[Primary malignant lymphoma of the ureter: a case report]
Hiromitsu Fujisawa1, Hiroshi Takagane, Kenji Shimosegawa
1Department of Urology, Iwate Prefectural Miyako Hospital.
Insights
A rare case of ureteral non-Hodgkin lymphoma (NHL) was initially misdiagnosed as transitional cell carcinoma. This large B-cell lymphoma was successfully treated with chemotherapy, with the patient remaining disease-free for 15 months.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Ureteral tumors are rare, with transitional cell carcinoma being the most common malignancy.
- Accurate diagnosis is crucial for appropriate treatment and patient outcomes.
Observation:
- A 58-year-old man presented with right hydronephrosis, revealing a ureteral mass on imaging.
- Initial urine cytology suggested transitional cell carcinoma, leading to nephro-ureterectomy and partial cystectomy.
- Histopathology confirmed non-Hodgkin lymphoma (large B-cell type) of the ureter, classified as Clinical Stage IE.
Findings:
- The patient received one course of systemic chemotherapy (THP-cop) but experienced severe thrombocytopenia.
- Despite treatment limitations, no recurrence was observed 15 months post-operation.
Implications:
- This case highlights the importance of thorough histopathological examination to differentiate ureteral malignancies.
- Non-Hodgkin lymphoma of the ureter, though rare, can be managed effectively, even with treatment complications.
- Further research into optimal chemotherapy regimens for ureteral lymphoma is warranted.
Abstract:
A 58-year-old man who had right hydronephrosis pointed out by medical checkup visited our hospital. Computed tomography and retrograde pyelography revealed a soft tissue mass in the middle portion of the right ureter. Urine cytology specimen from the right ureter suggested transitional cell carcinoma. Under the diagnosis of right ureteral cancer, we performed right total nephro-ureterectomy, partial cystectomy. The histopathological examination showed non-Hodgkin lymphoma (large B-cell type) of the ureter. Our diagnosis was Clinical Stage IE of the Ann Arbor Classification. The patient received only the first course of systemic chemotherapy (THP-cop), because he suffered severe thrombocytopenia in the course of the chemotherapy. No recurrence was found for 15 months after operation, and at present he is disease-free.
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