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[Non-A non-B hepatitis associated with cytomegalovirus infection]

V Sanchis-Bayarri Vaillant1, M T Fraile Fariñas, V Sanchis-Bayarri Bernal

  • 1Servicio de Análisis Clínicos, Hospital General Universitario, Valencia.

Anales De Medicina Interna (Madrid, Spain : 1984)
|February 1, 1991
PubMed

Insights

A patient with kidney failure experienced a cytomegalovirus reactivation after a blood transfusion, leading to hepatitis. This case highlights cytomegalovirus as a potential cause of non-A, non-B hepatitis in immunocompromised individuals.

Area of Science:

  • Clinical Medicine
  • Virology
  • Nephrology

Background:

  • A 58-year-old male with end-stage renal disease on dialysis presented with non-A, non-B hepatitis.
  • The patient had received a transfusion of packed red blood cells.

Observation:

  • Post-transfusion, IgG antibodies against cytomegalovirus (CMV) significantly increased (ELISA detected 1/160 to 1/1560).
  • Elevated GPT levels (up to 404 UI/ml) were observed, while total bilirubin remained normal.

Findings:

  • The clinical presentation suggests a potential causal link between cytomegalovirus reactivation and non-A, non-B hepatitis in this immunocompromised patient.
  • The findings align with observations of CMV-induced hepatitis in immunosuppressed renal transplant recipients.

Implications:

  • Cytomegalovirus should be considered in the differential diagnosis of hepatitis in patients with compromised immune systems, particularly those undergoing dialysis or post-transplantation.
  • This case underscores the importance of monitoring for viral reactivation in immunocompromised populations following medical interventions like blood transfusions.

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