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Acute lymphoblastic leukemia: diagnosis and detection of minimal residual disease following therapy

Joseph A Digiuseppe1

  • 1Department of Pathology & Laboratory Medicine, Special Hematology Laboratory, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102-5037, USA. jdigius@harthosp.org

Clinics in Laboratory Medicine
|July 31, 2007
PubMed

Insights

Flow cytometric immunophenotyping (FCI) aids in diagnosing acute lymphoblastic leukemia (ALL) by identifying leukemic cells. This method also detects minimal residual disease, crucial for prognosis and tailored treatments.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Acute lymphoblastic leukemia (ALL) diagnosis relies on accurate methods.
  • Flow cytometric immunophenotyping (FCI) is a key diagnostic tool.

Purpose of the Study:

  • To highlight the role of FCI in diagnosing and managing ALL.
  • To emphasize FCI's prognostic value in minimal residual disease detection.

Main Methods:

  • Utilizing flow cytometry for rapid identification and characterization of leukemic blasts.
  • Employing FCI for sensitive detection of minimal residual disease post-therapy.

Main Results:

  • FCI enables accurate and timely diagnosis of ALL.
  • FCI can predict cytogenetic and molecular abnormalities.
  • Minimal residual disease detection by FCI is a strong prognostic indicator.

Conclusions:

  • FCI is essential for ALL diagnosis, classification, and prognosis.
  • FCI facilitates risk-adapted therapy through precise minimal residual disease monitoring.

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