Immune-mediated canine and feline keratitis

Area of Science:

• Veterinary Ophthalmology
• Immunology

Background:

• The cornea normally lacks blood vessels and lymphatic vessels.
• Despite this, immune-mediated conditions affecting the cornea can occur in companion animals.
• Understanding corneal immunology is crucial for diagnosing and managing these diseases.

Purpose of the Study:

• To provide an overview of corneal immunology.
• To discuss specific immune-mediated corneal diseases in dogs and cats.

Main Methods:

• Literature review of corneal immunology.
• Discussion of clinical presentations and underlying mechanisms of selected canine and feline corneal diseases.

Main Results:

• Several immune-mediated corneal conditions affect dogs and cats.
• Canine diseases include chronic superficial keratitis, superficial punctate keratitis, and canine adenovirus endotheliitis.
• Feline diseases include eosinophilic keratitis and herpesvirus-related conditions.

Conclusions:

• Immune responses play a significant role in various corneal pathologies in dogs and cats.
• Recognition of these conditions is essential for appropriate veterinary care.
• Further research into corneal immune mechanisms can improve treatment strategies.