Related Experiment Video

Updated: Aug 12, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

[Changes in immunologic phenotype of cells in hairy cell leukemia]

L V Muskhelishvili, M V Mandzhgaladze, K Ts Keniia

    Gematologiia I Transfuziologiia
    |October 1, 1990
    PubMed

    Insights

    Hairy-cell leukemia (HCL) cells can change their immune markers over time, losing B-cell indicators and gaining T-cell markers. This immune phenotype shift can complicate diagnosis, potentially leading to misclassification as T-cell HCL.

    Area of Science:

    • Hematology
    • Immunology
    • Oncology

    Background:

    • Hairy-cell leukemia (HCL) is a rare B-cell malignancy.
    • Diagnosis typically relies on characteristic immunophenotyping of malignant cells.

    Observation:

    • A unique case of HCL is presented where the neoplastic clone underwent significant changes.
    • Over time, the pathological cells lost surface immunoglobulins, a hallmark of B-cell lineage.

    Findings:

    • The malignant cells acquired membrane markers typically associated with the T-lymphoid series.
    • This alteration in immunological phenotype represents a deviation from classical HCL presentation.

    Implications:

    • The observed immunophenotypic shift poses a diagnostic challenge.
    • Misdiagnosis of T-cell HCL is a potential consequence, highlighting the need for careful evaluation in evolving HCL cases.

    More Related Videos

    Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells10:21

    Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

    Published on: February 21, 2018

    In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells10:26

    In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

    Published on: January 20, 2019

    Related Concept Videos

    Cells of the Adaptive Immune Response01:23

    Cells of the Adaptive Immune Response

    The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
    B Cell Activation and Differentiation01:24

    B Cell Activation and Differentiation

    The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
    When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...