Related Experiment Video

Updated: May 11, 2026

Quantification of Microglial Engulfment of Synaptic Material Using Flow Cytometry
07:41

Quantification of Microglial Engulfment of Synaptic Material Using Flow Cytometry

Published on: May 31, 2024

[Neuroimmunology: theoretical and clinical aspects]

I D Stoliarov, A M Petrov, M V Votintseva

    Fiziologiia Cheloveka
    |May 15, 2013
    PubMed

    Insights

    This article discusses neuroimmune interactions in conditions like cerebral ischemia, stroke, multiple sclerosis, and secondary immunodeficiency, integrating experimental and clinical findings.

    Area of Science:

    • Neuroimmunology
    • Neurology
    • Immunology

    Context:

    • Neuroimmune interactions are crucial in neurological disorders.
    • Cerebral ischemia and stroke involve complex immune responses.
    • Multiple sclerosis is characterized by demyelination and immune system involvement.
    • Secondary immunodeficiency can impact neurological health.

    Purpose:

    • To review the multifaceted roles of neuroimmune interactions in various neurological conditions.
    • To present experimental and clinical data on neuroimmune responses.
    • To discuss the demyelinating process in multiple sclerosis and secondary immunodeficiency.

    Summary:

    • The article examines neuroimmune interactions in cerebral ischemia and stroke, drawing on both experimental and clinical evidence.
    • It further explores the demyelinating process observed in multiple sclerosis patients.
    • The role of secondary immunodeficiency in the context of neuroimmune interactions is also discussed.

    Impact:

    • Provides a comprehensive overview of neuroimmune interactions in key neurological diseases.
    • Integrates diverse data sources, including experimental findings and clinical observations.
    • Offers insights into the mechanisms underlying stroke, multiple sclerosis, and immunodeficiency-related neurological issues.

    More Related Videos

    Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination09:38

    Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

    Published on: September 12, 2016

    Related Concept Videos

    Encephalitis ll: Pathophysiology01:26

    Encephalitis ll: Pathophysiology

    Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
    Psychoneuroimmunology: Diabetes and Cancer01:19

    Psychoneuroimmunology: Diabetes and Cancer

    Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
    Psychoneuroimmunology: Cardiovascular Disease01:27

    Psychoneuroimmunology: Cardiovascular Disease

    Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
    A key area of focus in PNI is the relationship between stress and coronary...
    Bacterial Meningitis II: Pathophysiology01:26

    Bacterial Meningitis II: Pathophysiology

    Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
    Neurochemical Transmission: Sites of Drug Action01:26

    Neurochemical Transmission: Sites of Drug Action

    Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
    Introduction to Biological Bases of Psychology01:30

    Introduction to Biological Bases of Psychology

    Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
    The nervous system, the cornerstone of...