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[The expression of IL-22 in nasal polyps tissues]

L Xiao1, L Bai2, M Y Liu1

  • 1Three Gorges University Medical School, Yichang, 443002, China.

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
|May 26, 2018
PubMed

Insights

Nasal polyps show increased levels of Th22 cells, a type of immune cell. This suggests Th22 cells may contribute to chronic inflammation in the nasal lining.

Area of Science:

  • Immunology
  • Otolaryngology

Background:

  • Nasal polyps are associated with chronic inflammation.
  • The role of specific T helper cell subsets, like Th22 cells, in nasal polyposis is not fully understood.

Purpose of the Study:

  • To investigate the expression of Interleukin-22 (IL-22) and Th22 cells in nasal polyps.
  • To determine the association between IL-22, Th22 cells, and chronic inflammation in nasal polyps.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure IL-22 concentrations in nasal polyp tissue.
  • Flow cytometry was employed to analyze IL-22 expression in CD4+ T cells and quantify Th22 cell counts within infiltrated mononuclear cells from nasal polyps.

Main Results:

  • While overall IL-22 expression in nasal polyps did not significantly differ from controls, IL-22 expression within CD4+ T cells was elevated.
  • A significant increase in the number of Th22 cells was observed in nasal polyp tissues compared to the control group.

Conclusions:

  • Nasal polyps exhibit a significant upregulation of Th22 cells.
  • These findings suggest that Th22 cells play a crucial role in the local chronic inflammatory mucosal immune response within nasal polyps.

Keywords:
IL-22Th22 cellsnasal polyps

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