Related Experiment Video

Updated: Feb 26, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.5K

Biological age and immunosenescence in Colombian centenarians

Juan-Manuel Anaya1,2, Edward A Ruiz-Narváez3, Ivan David Lozada-Martinez4,5

  • 1Colombian Centenarians Alliance, Bogotá, Colombia. anayajm@gmail.com.

Npj Aging
|February 24, 2026
PubMed

Insights

Centenarians show varied biological aging, with better well-being linked to younger biological age. Distinct immune cell profiles and clinical factors correlate with advanced biological age, challenging typical immunosenescence notions in extreme longevity.

Area of Science:

  • Geroscience
  • Immunology
  • Longevity Research

Background:

  • Biological aging and immunosenescence are key to longevity.
  • Their interaction in centenarians is not well understood.
  • Centenarians represent a unique model for studying aging.

Purpose of the Study:

  • To investigate the relationship between biological age (PhenoAge) and immunosenescence in Colombian centenarians.
  • To identify clinical variables associated with biological age and immune status.
  • To explore immune profiles in different centenarian aging trajectories.

Main Methods:

  • Cross-sectional study of 160 Colombian centenarians.
  • Assessed biological age using PhenoAge.
  • Performed cytokine profiling and lymphocyte immunophenotyping.
  • Collected data on quality of life, well-being, and clinical variables.

Main Results:

  • Higher biological age associated with depressive symptoms, smoking history, elevated RANTES and G-CSF, and specific CD8+ T cell phenotypes (e.g., TEMRA cells).
  • Better quality of life and well-being linked to lower biological age.
  • Centenarians categorized as vigorous, resilient, or vulnerable showed similar cytokine levels.

Conclusions:

  • Findings challenge the universal concept of immunosenescence in centenarians.
  • Biological age is associated with specific clinical and immune factors in extreme longevity.
  • Highlights the importance of translational geroscience research.

More Related Videos

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

564
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

4.2K

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.0K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
278
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
894
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
761
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
267
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
298