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Updated: Jun 4, 2026

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

SECTM1 coordinates immune microenvironments and multi-systemic disease pathophysiology

Wenqing Yu1, Yusheng Wu1, Mingdong Ding1

  • 1Department of Infectious Diseases, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, China.

Frontiers in Immunology
|June 3, 2026
PubMed

Insights

Secreted and Transmembrane Protein 1 (SECTM1) is a versatile immunomodulator bridging innate and adaptive immunity. This review highlights its expanded roles in diverse diseases and potential for precision immunotherapy.

Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • Secreted and Transmembrane Protein 1 (SECTM1) was initially known as a co-stimulatory molecule interacting with CD7 on T cells.
  • Emerging evidence reveals SECTM1's broader function as a bridge between innate and adaptive immunity.
  • SECTM1 also interacts with receptors like glucocorticoid-induced TNFR-related protein, modulating macrophage and neutrophil activity.

Purpose of the Study:

  • To review the expanded understanding of SECTM1's immunomodulatory functions.
  • To delineate SECTM1's molecular mechanisms in various pathologies.
  • To highlight SECTM1's potential as a diagnostic biomarker and therapeutic target.

Main Methods:

  • Systematic review of existing literature on SECTM1.
  • Analysis of SECTM1's interactions with immune receptors.
  • Examination of SECTM1's role in diverse disease contexts.

Main Results:

  • SECTM1 acts as a multi-systemic regulator influencing tumor microenvironment, metabolic homeostasis, and tissue regeneration.
  • SECTM1 governs immune cell migration and activation in cancer, cardiovascular, and neurodegenerative diseases.
  • SECTM1 is identified as a marker of "immune-hot" tumors and a potential early diagnostic biomarker.

Conclusions:

  • SECTM1's role extends beyond lymphoid signaling to encompass diverse systemic functions.
  • SECTM1 presents significant clinical potential for precision immunotherapy and regenerative medicine.
  • Further research into SECTM1 mechanisms could unlock novel therapeutic strategies.

Keywords:
CD7/GITR axisbiomarkerimmune checkpointinnate-adaptive crosstalksecreted and transmembrane protein 1 (SECTM1)tumor microenvironment

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