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[Lymphoplasmocytoid immunocytoma of the skin]
R Brehler1, J Grabbe, M Bergholz
1Zentrum für Dermatologie und Venerologie.
Insights
A rare skin lymphoma, cutaneous lymphoplasmocytoid immunocytoma, presented as red-brown papules. Total-body irradiation effectively treated this localized B-cell lymphoma.
Area of Science:
- Dermatology
- Oncology
- Hematology
Background:
- Cutaneous lymphoplasmocytoid immunocytoma is a rare B-cell lymphoma primarily affecting the skin.
- Understanding its clinical presentation and treatment is crucial for patient outcomes.
Observation:
- A 68-year-old male presented with multiple red-brown papules on the trunk and neck.
- Histological and electron microscopy confirmed atypical lymphoid cells in the dermis.
Findings:
- Immunohistochemistry identified a monoclonal proliferation of IgG-kappa-positive B-lymphocytes, confirming the diagnosis.
- The lymphoma was confined to the skin, with no evidence of extracutaneous spread.
Implications:
- Complete remission was achieved using total-body irradiation with an electron beam.
- This case highlights the efficacy of radiation therapy for localized cutaneous B-cell lymphomas.
Abstract:
A 68-year-old male patient presented with numerous red-brown papules on the trunk and neck. Cutaneous lymphoplasmocytoid immunocytoma was diagnosed following histological and electron microscopical detection of atypical lymphoid cells in the dermis. Immunohistochemistry revealed a monoclonal proliferation of IgG-kappa-positive B-lymphocytes. There was no extracutaneous manifestation of the lymphoma. Complete remission was affected by total-body irradiation with an electron beam.