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Estructura y función de un módulo TAFII250 humano de doble bromodomaína
R H Jacobson1, A G Ladurner, D S King
1Howard Hughes Medical Institute and Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720-3204, USA.
Science (New York, N.Y.)
|May 29, 2000
Resumen
El complejo TFIID reconoce colas de histona H4 acetiladas a través de su subunidad TAFII250. Esta interacción bromodomain sugiere un mecanismo para la orientación de los factores de transcripción a los promotores de la cromatina.
Área de la Ciencia:
- Biología Molecular Biología Molecular
- Biología de la cromatina Biología de la cromatina
- Transcripción genética de la transcripción de genes.
Sus antecedentes:
- El factor de transcripción II D (TFIID) es crucial para iniciar la transcripción génica.
- Los mecanismos por los cuales el TFIID reconoce promotores ligados al nucleosoma in vivo siguen siendo en gran medida desconocidos.
Objetivo del estudio:
- Para investigar cómo TFIID interactúa con el ADN nucleosómico para iniciar la transcripción.
- Para aclarar el papel de la subunidad TAFII250 en el reconocimiento del promotor.
Principales métodos:
- Cristalografía de rayos X para determinar la estructura de TAFII250 bromodomains.
- Pruebas bioquímicas para evaluar la afinidad de unión a los péptidos de histona acetilada.
Principales resultados:
- TAFII250, la subunidad TFIID más grande, posee módulos de bromodomaínas en tándem.
- Estos bromodomaines se unen selectivamente a los péptidos H4 de histona acetilados multiplicados.
- La estructura cristalina revela una arquitectura única adecuada para el reconocimiento de colas H4 de histona diacetilada.
Conclusiones:
- TFIID utiliza bromodomaínos TAFII250 para el reconocimiento específico de la histona H4 acetilada.
- Esta interacción proporciona un mecanismo potencial para dirigir el TFIID a los promotores unidos a la cromatina.
- TFIID puede desempeñar un papel directo en el reconocimiento de la cromatina durante la iniciación de la transcripción.
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