Video Experimental Relacionado

Updated: Jul 21, 2026

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
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Published on: July 29, 2014

PKR y eIF2alpha: integración de la dimerización de la quinasa, la activación y el acoplamiento del sustrato

Susan S Taylor1, Nina M Haste, Gourisankar Ghosh

  • 1Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093, USA.

Cell
|September 24, 2005
PubMed
Resumen

La proteína quinasa dependiente del ARN (PKR) se une al ARN viral para detener la síntesis de proteínas. Los estudios estructurales revelan cómo la PKR se dimeriza para activar y unirse a su sustrato, eIF2alfa, lo que permite la defensa antiviral.

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