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La experiencia in vivo en curso desencadena la metaplasticidad sináptica en el neocórtex
Roger L Clem1, Tansu Celikel, Alison L Barth
1Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Science (New York, N.Y.)
|January 5, 2008
Resumen
La experiencia sensorial en curso inicialmente dificulta, luego promueve el fortalecimiento sináptico en la corteza del barril del ratón. Esto sugiere un mecanismo dinámico donde la experiencia continua refina las representaciones neuronales con el tiempo.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La plasticidad sináptica.
- Procesamiento Sensorial Procesamiento Sensorial
Sus antecedentes:
- La experiencia in vivo puede afectar la potenciación a largo plazo (LTP) y mejorar la depresión a largo plazo (LTD).
- Esto sugiere que la experiencia continua podría degradar las representaciones neuronales, lo que contradice los principios de aprendizaje.
Objetivo del estudio:
- Para investigar cómo la estimulación continua de los bigotes afecta el fortalecimiento sináptico en la corteza de barril del ratón.
- Aclarar los mecanismos moleculares subyacentes a la plasticidad sináptica dependiente de la experiencia.
Principales métodos:
- Registros electrofisiológicos in vivo e in vitro en la corteza del cañón del ratón.
- Examinó las respuestas sinápticas en las sinapsis de la capa 4-2/3 durante la estimulación sensorial en curso.
- Investigó las funciones del N-metil-d-aspartato (NMDA) y los receptores metabotrópicos de glutamato (mGluR).
Principales resultados:
- La activación del receptor NMDA era necesaria para el fortalecimiento sináptico inicial, pero más tarde suprimió la potenciación adicional.
- La actividad sensorial continua indujo un mayor fortalecimiento sináptico.
- Este fortalecimiento posterior requirió la activación del receptor metabotrópico del glutamato, no de los receptores NMDA.
Conclusiones:
- La plasticidad sináptica exhibe un cambio en el mecanismo durante la entrada sensorial sostenida.
- Los receptores metabotrópicos de glutamato median el fortalecimiento sináptico dependiente de la experiencia después de la potenciación inicial dependiente del receptor NMDA.
- Esto proporciona un mecanismo para cómo la experiencia continua mejora las representaciones neuronales a lo largo del tiempo.
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