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Updated: Jul 15, 2026

Generation of Maternal Mutants Using zpc:cas9 Knock-in Zebrafish
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Generation of Maternal Mutants Using zpc:cas9 Knock-in Zebrafish

Published on: July 22, 2025

ゲルムラインのpiRNAsは

Haifan Lin1

  • 1Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06510, USA. haifan.lin@yale.edu

Science (New York, N.Y.)
|April 21, 2007
PubMed
まとめ

小さな非コーディングRNAは遺伝子発現を調節する. 新たに発見されたクラスであるPiwi相互作用RNAs (piRNAs) は,Piwiタンパク質と相互作用し,生殖細胞における独特の調節経路を表しています.

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piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
Non-nuclear Inheritance01:29

Non-nuclear Inheritance

Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.