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Updated: Jan 5, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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設計直角信号経路は,シーケンススペースの少ない占有を明らかにします

Conor J McClune1,2, Aurora Alvarez-Buylla1, Christopher A Voigt2

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

Nature
|October 25, 2019
PubMed
まとめ

研究者は,機能的なキナーゼ基板ペアを設計することによって,大腸菌で新しいシグナル伝達経路を作成しました. これは,配列空間が混雑していないことを示し,新しい,隔離された細胞経路の簡単な進化または新しい設計を可能にします.

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