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Updated: Jun 4, 2025

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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エンジニアリングによる染色体外腫瘍遺伝子の増幅は,腫瘍発生を促進する

Davide Pradella1, Minsi Zhang1,2, Rui Gao1,3

  • 1Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature
|December 18, 2024
PubMed
まとめ

科学者は細胞とマウスのクロモソーム外DNA (ecDNA) を用いて大きな焦点遺伝子増幅を設計した. この発見により 癌に関連した変異を研究し 新しい臨床前がんモデルを開発することができます

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